IgA Nephropathy (Progressed)

• Kidney biopsy report, including the Oxford MEST-C scores, the number of glomeruli sampled and any crescents or scarring.
• Serial creatinine and eGFR results over at least a year, to show how fast kidney function is declining.
• Urine protein-to-creatinine ratio or 24-hour protein results, and blood pressure readings over time.
• Treatment history, including ACE inhibitors, ARBs, steroids or other immunosuppression, and how you responded.
• Transplant work-up so far: blood group, tissue typing, infection screening, and any donor offer or living-donor evaluation.

1. What stage is my kidney disease, and how quickly is my eGFR falling?
2. Is any active inflammation still present that treatment could slow, or is the damage mostly scarring?
3. When should I start preparing for dialysis access or a pre-emptive transplant?
4. Could a living donor be an option, and what is the chance that IgA nephropathy returns in the new kidney?
5. What anti-rejection medicines would I need, and how will they be followed up when I return home?
6. What can I do now about blood pressure, salt and protein intake to protect remaining function?

IgA nephropathy varies widely. Some people keep stable function for decades, while others reach kidney failure over ten to twenty years. Heavy proteinuria, high blood pressure and scarring on biopsy predict faster decline. Once failure is reached, a transplant usually gives better survival and quality of life than dialysis. The disease can recur in the graft, though it rarely causes early loss.